diff --git a/agents/runtime.go b/agents/runtime.go
index 56dad09..fa21eb7 100644
--- a/agents/runtime.go
+++ b/agents/runtime.go
@@ -22,6 +22,7 @@ import (
 	"github.com/enmanuel/agents/pkg/memory"
 	"github.com/enmanuel/agents/pkg/orchestration"
 	"github.com/enmanuel/agents/pkg/personality"
+	"github.com/enmanuel/agents/pkg/sanitize"
 	"github.com/enmanuel/agents/shell/bus"
 	"github.com/enmanuel/agents/shell/effects"
 	shellknowledge "github.com/enmanuel/agents/shell/knowledge"
@@ -83,6 +84,9 @@ type Agent struct {
 	// Knowledge store — non-nil when knowledge is enabled
 	knowledgeStore *shellknowledge.FileStore
 
+	// Sanitization options — nil when sanitization is disabled
+	sanitizeOpts *sanitize.Options
+
 	// Bus — set via SetBus() when running under the unified launcher
 	agentBus *bus.Bus
 }
@@ -246,6 +250,20 @@ func New(cfg *config.AgentConfig, rules []decision.Rule, logger *slog.Logger) (*
 		roomCtx:        roomCtx,
 	}
 
+	// Configure sanitization if enabled
+	if cfg.Security.Sanitize.Enabled {
+		minSev := parseSeverity(cfg.Security.Sanitize.MinSeverity)
+		a.sanitizeOpts = &sanitize.Options{
+			Mode:             sanitize.ParseMode(cfg.Security.Sanitize.Mode),
+			MinSeverity:      minSev,
+			DisabledPatterns: cfg.Security.Sanitize.DisabledPatterns,
+		}
+		logger.Info("input sanitization enabled",
+			"mode", a.sanitizeOpts.Mode,
+			"min_severity", minSev,
+		)
+	}
+
 	// Register built-in command handlers
 	a.registerBuiltinCommands()
 
@@ -424,6 +442,16 @@ func (a *Agent) handleTaskEvent(ctx context.Context, msg bus.AgentMessage) {
 			"\n\nPlease provide an improved or complementary answer."
 	}
 
+	// Sanitize orchestrated input
+	sanitized, rejected := a.sanitizeInput(msgCtx.Content, roomID, msgCtx.SenderID)
+	if rejected {
+		a.logger.Warn("orchestrated task rejected by sanitizer",
+			"task_id", task.TaskID, "sender", task.OriginalSender)
+		_ = a.matrix.SendMarkdown(ctx, roomID, "El mensaje fue rechazado por el filtro de seguridad.")
+		return
+	}
+	msgCtx.Content = sanitized
+
 	// Load memory and run LLM
 	a.ensureWindowLoaded(ctx, roomID)
 	a.appendToWindow(roomID, coretypes.Message{
@@ -580,6 +608,17 @@ func (a *Agent) handleEvent(ctx context.Context, msgCtx decision.MessageContext,
 
 // executeActions expands LLM actions and runs the effects runner.
 func (a *Agent) executeActions(ctx context.Context, roomID string, msgCtx decision.MessageContext, actions []decision.Action) {
+	// Sanitize user input before sending to LLM
+	sanitized, rejected := a.sanitizeInput(msgCtx.Content, roomID, msgCtx.SenderID)
+	if rejected {
+		a.runner.Execute(ctx, roomID, []decision.Action{{
+			Kind:  decision.ActionKindReply,
+			Reply: &decision.ReplyAction{Content: "Tu mensaje fue rechazado por el filtro de seguridad.", InReplyTo: msgCtx.EventID},
+		}})
+		return
+	}
+	msgCtx.Content = sanitized
+
 	expanded := make([]decision.Action, 0, len(actions))
 	for _, act := range actions {
 		if act.Kind == decision.ActionKindLLM {
@@ -806,6 +845,40 @@ func (a *Agent) persistMessage(ctx context.Context, roomID string, role coretype
 	}
 }
 
+// parseSeverity converts a config string to sanitize.Severity.
+func parseSeverity(s string) sanitize.Severity {
+	switch s {
+	case "high":
+		return sanitize.SeverityHigh
+	case "low":
+		return sanitize.SeverityLow
+	default:
+		return sanitize.SeverityMedium
+	}
+}
+
+// sanitizeInput runs prompt injection detection on the message content.
+// Returns the (possibly modified) content and true if the message should be rejected.
+func (a *Agent) sanitizeInput(content, roomID, senderID string) (string, bool) {
+	if a.sanitizeOpts == nil {
+		return content, false
+	}
+
+	result := sanitize.Sanitize(content, *a.sanitizeOpts)
+
+	for _, w := range result.Warnings {
+		a.logger.Warn("prompt_injection_detected",
+			"pattern", w.PatternName,
+			"severity", w.Severity,
+			"matched", w.Matched,
+			"sender", senderID,
+			"room", roomID,
+		)
+	}
+
+	return result.Output, result.Rejected
+}
+
 // buildToolRegistry creates a Registry with tools enabled in the agent's config.
 func buildToolRegistry(
 	cfg *config.AgentConfig,
diff --git a/internal/config/schema.go b/internal/config/schema.go
index 0d209cc..a7f2fae 100644
--- a/internal/config/schema.go
+++ b/internal/config/schema.go
@@ -280,9 +280,18 @@ type SSHTargetCfg struct {
 // ── Security ──────────────────────────────────────────────────────────────
 
 type SecurityCfg struct {
-	Roles   map[string]RoleCfg `yaml:"roles"`
-	Audit   AuditCfg           `yaml:"audit"`
-	Secrets SecretsCfg         `yaml:"secrets"`
+	Roles    map[string]RoleCfg `yaml:"roles"`
+	Audit    AuditCfg           `yaml:"audit"`
+	Secrets  SecretsCfg         `yaml:"secrets"`
+	Sanitize SanitizeCfg        `yaml:"sanitize"`
+}
+
+// SanitizeCfg controls prompt injection detection on incoming messages.
+type SanitizeCfg struct {
+	Enabled          bool     `yaml:"enabled"`           // enable sanitization (default false)
+	Mode             string   `yaml:"mode"`              // warn | strip | reject (default warn)
+	MinSeverity      string   `yaml:"min_severity"`      // low | medium | high (default medium)
+	DisabledPatterns []string `yaml:"disabled_patterns"` // pattern names to skip
 }
 
 type RoleCfg struct {